To observe the clinical effects of moxibustion combined with Jianpi Shengxue Granule in treating insomnia of heart and spleen deficiency syndrome.Methods：A total of 123 patients with insomnia of heart and spleen deficiency syndrome in Bazhong Hospital of Traditional Chinese Medicine from March 2015 to December 2018 were selected as research subjects.They were randomly divided into 2 groups：62 patients in the observation group and 61 patients in the control group,All the patients in 2 groups selected points based on the syndrome differentiation including Guanyuan(RN4),Baihui(DU20）and bilateral Zusanli(ST36）and other acupuncture points,and moxibustion treatment was given.The observation group was added with oral administration of Jianpi Shengxue Granule.Indexes including improvement of sleep quality,clinical efficacy and insomnia recurrence rate in the 2 groups were observed.Results：After treatment,the Pittsburgh sleep quality index(PSQI）and TCM symptom scores were improved in the 2 groups,and the difference was statistically significant(P<0.05); the total effective rate was 92.7% in the observation group and 75.2% in the control group.The clinical efficacy of the observation group was significantly better than that of the control group,and the difference was statistically significant(P<0.05).After 3 months of follow-up period,1 patient(4.3%）relapsed in the observation group and 5 patients relapsed in the control(only moxbustion therapy）group(31.3%),and the observation group was significantly better than the simple moxibustion group(P<0.05).Conclusion：Moxibustion combined with Jianpi Shengxue Granule is effective in treating insomnia of heart and spleen deficiency syndrome.The combination of the 2 treatments can significantly improve sleep quality,especially for patients with high recurrence rate.Treatment combined with Jianpi Shengxue Granule can reduce the probability of recurrence,which is worthy of clinical promotion.