To study the clinical efficacy of Danshen Chuanxiongqin Injection in patients with cerebral thrombosis and its effects on the content of superoxide dismutase(SOD), malondialdehyde(MDA), lysophosphatidic acid(LPA)and endothelin(ET-1).Methods:A total of 78 patients with cerebral thrombosis admitted in the People's Liberation Army 281 Hospital during March 2015 to February 2018 were selected and randomly divided into a control group(n=39, routine western medicine treatment)and an observation group(n=39, routine western medicine treatment combind with Danshen Chuanxiongqin Injection).Therapeutic effect, functional score, and the content of serum SOD, MDA, LPA and ET-1 were observed.Results:The overall efficacy in the observation group was better than that in the control group(P<0.05); 7 days after the treatment, the clinical symptom scores of stroke, TCM syndrome scores, NIHSS scores and serum content of MDA, LPA, and ET-1 in the 2 groups were significantly decreased, and the serum SOD content was significantly increased(P<0.05).The clinical symptom score of stroke, TCM syndrome scores, NIHSS score and serum content of MDA, LPA and ET-1 in the observation group were significantly lower than those in the control group, and the serum SOD content was significantly higher than that in the control group(P<0.05).Conclusion:Danshen Chuanxiongqin Injection in the treatment of cerebral thrombosis can improve the efficacy, improve symptoms and relieve oxidative stress.