To observe the therapeutic effects of Renshen Guben Oral Liquid combined with prednisone in the treatment of nephrotic syndrome and to provide references for clinical medicine.Methods:From March 2017 to Feburary 2018,108 patients with nephrotic syndrome admitted by The Affiliated Hospital of Southwest Medical University were randomly divided into 3 groups-a control group,a low dose observation group A and a high dose observation group B,with 36 patients in each group.Patients in the control group received the treatment of prednisone and initial dose of prednisone,which was less than 60 mg/d,was 1.0 mg/(kg·d).Daily dose reduced 10% per week to 20 mg/d,which would be maintained for 2 months,when urine test showed urine protein,or 4 weeks later.After daily dose of 20 mg,dose of 10 mg/d would be maintained until the end of the course.Patients in low dose observation group A received the treatment of low dose of Renshen Guben Oral Liquid on the basis of the same treatment of prednisone in control group.During first week,initial dose of Renshen Guben Oral Liquid was 10 mL at a time,twice per day.Daily dose would be once per day during the second week.After that,the dose reduced to 5 mL at a time in 2 days for the last 2 weeks of the course.Patients in high dose observation group B received the treatment of high dose of Renshen Guben Oral Liquid besides the same treatment of prednisone in control group.During first week,initial dose of Renshen Guben Oral Liquid was 10 mL,twice per day.After that,daily dose would be 10 mL,which would be maintained until the end of the course.Results:The difference of cure rate among the 3 groups was significant.The total cure rates of the observation group A and B were 94.44% and 97.22% respectively,which were better than those of control group 77.22%.The difference was statistically significant(P<0.05),while the difference between the 2 observation groups was not statistically significant(P>0.05).There were also significant differences of 24-hour urine protein quantitation,BUN,TC and TG among the 3 groups.The difference between group A and group B was still not statistically significant(P>0.05).As for the adverse reactions in test groups,the incidence of group A was lower than that of group B.Conclusion:Therapeutic effect of Renshen Guben Oral Liquid combined with prednisone is better than prednisone alone in the treatment of nephrotic syndrome.However,low dose of Renshen Guben Oral Liquid is recommended to combine with prednisone in the treatment of nephrotic syndrome.