To explore clinical efficacy and mechanism of Qingxin Zishen Decoction in premature ovarian insufficiency(POI)of heart-kidney non-interaction type under the guidance of “heart-kidney-uterus axis” theory.Methods:A total of 88 patients with POI of heart-kidney non-interaction type who were eligible in the Kunshan Traditional Chinese Medicine Hospital from April 2017 to April 2018 were selected as research objects and randomly divided into a control group(44 cases)and an observation group(44 cases)according to the order of treatment.The control group was given cyclic sequential treatment of estrogen and progesterone.The observation group was additionally treated with modified Qingxin Zishen Decoction under the guidance of “heart-kidney-uterus axis” theory on the treatment basis of the control group.Both groups were treated continuously for 3 months.Levels of sex hormone and anti-Mullerian hormone(AMH)before and after the treatment were observed and compared between the 2 groups.Average diameter of ovary, ovarian area and antral follicle count in B-ultrasound before and after the treatment were observed.Changes of life quality before and after the treatment were observed and compared.During the treatment, adverse reactions were compared and symptomatic treatment was performed.The efficacy was judged after the treatment.Results:1)There was no significant difference in the levels of FSH, LH, E2 and AMH between the 2 groups before the treatment(P>0.05).The levels of FSH and LH in the end of the treatment were significantly lower than those before the treatment, while the levels of E2 and AMH were significantly higher than those before the treatment(P<0.05).And the above indexes in the observation group were significantly better than those in the control group(P<0.05).2)There was no significant difference in the average diameter of ovary, ovarian area and antral follicle count before the treatment between the 2 groups(P>0.05).At the end of treatment, the above indexes were significantly increased in the 2 groups compared with those before the treatment(P<0.05).And the above indexes in the observation group were significantly better than those in the control group(P<0.05).3)There was no significant difference in physiological function, physical function, somatic pain, general health, vitality, social function, emotional function and mental health between the 2 groups before the treatment(P>0.05).After the treatment, the above indexes in the 2 groups were significantly higher than those before the treatment(P<0.05), and the above indexes in the observation group were significantly higher than those in the control group(P<0.05).4)After the treatment, the cure rate and total effective rate in the observation group were significantly higher than those in the control group(P<0.05).5)There was no significant difference in the incidence of adverse reactions between the 2 groups(P>0.05).Conclusion:Qingxin Zishen Decoction in treatment of POI can improve the estrogen level, optimize ovarian function and improve the quality of life under the guidance of the theory of “heart-kidney-uterus axis”, with satisfying efficacy.