To explore the effects of Shengjing Zhongyu Decoction on the treatment of oligospermia and asthenospermia infertility and its influence on Caspase 3 and Caspase 8 in semen，and to provide reference for its clinical diagnosis and treatment.Methods:A total of 96 patients with oligospermia and asthenospermia infertility admitted to Huizhou Central People's Hospital from June 2015 to June 2018 were enrolled in the study.They were divided into a control group and an observation group according to random number method，with 48 cases each.The control group was treated with Wuzi Yanzong Pill.The patients in the observation group were treated with Shengjing Zhongyu Decoction.The parameters of semen and the changes of Caspase 3 and Caspase 8 in semen and sperm were compared before and after treatment.Results:Compared with before treatment，the sperm density，sperm survival rate，a-level sperm activity，a+b-level sperm activity and other semen parameters of the 2 groups were significantly increased，and the levels of caspase-3 and caspase-8 in semen and sperm were significantly decreased，and the improvement of the above indicators was more significant in the observation group(P<0.05).The effective rate of treatment in the observation group was 95.83%，which was significantly higher than 83.33% in the control group.The difference was statistically significant(P<0.05).Conclusion:Shengjing Zhongyu Decoction can significantly reduce the levels of Caspase 3 and Caspase 8 in semen，enhance the sperm motility，and treat the symptoms more effectively.It is worthy of clinical promotion.