To explore the clinical effect of Tianma Gouteng Decoction combined with butylphthalide in treatment of acute cerebral infarction(ACI).Methods:A total of 50 patients with ACI admitted to Traditional Chinese Hospital of Lu'an from June 2018 to April 2019 were selected as study objects and divided into a control group(n=25)and an observation group(n=25)according to random number table method.The control group was given routine treatment,while the observation group was given Tianma Gouteng Decoction combined with butylphthalide treatment.Clinical total effective rate of the 2 groups was counted; MDA,ox-LDL,SOD,GSH-PX level changes of the 2 groups were compared before and after treatment; NIHSS,MRS,BI scores of the 2 groups were observed before and after treatment.Results:After treatment,the NIHSS,MRS scores,MDA and ox-LDL levels in the observation group were significantly lower than those before treatment,and the NIHSS,MRS scores and MDA levels in the observation group were significantly lower than those in the control group(P<0.05); After treatment,the BI scores and SOD,GSH-PX levels in the observation group were significantly higher than those before treatment and the control group(P<0.05); After treatment,the total clinical efficiency of the observation group was significantly higher than that of the control group(P<0.05).Conclusion:Tianma Gouteng Decoction combined with butylphthalide can effectively improve the clinical symptoms of ACI patients,enhance the ability of scavenging free radicals,reduce oxidative stimulation response,alleviate cerebral ischemia injury,and improve the total clinical effective rate,and the therapeutic effect is better than routine treatment,which is worthy of clinical promotion and application.