To explore the therapeutic effects of Quyu Decoction combined with GP chemotherapy in the treatment of advanced lung cancer with yin deficiency and endogenous heat and its effect on serum tumor markers in patients.Methods:A total of 78 patients with advanced lung cancer admitted to Traditional Chinese Hospital of Luan from March 2016 to March 2018 were selected,and the enrolled patients were divided into a control group and an observation group with 39 patients in each group according to the random number table method.The control group was treated with GP chemotherapy regimen,and the observation group was treated with Quyu Decoction combined with GP chemotherapy regimen.The clinical efficacy,tumor markers,platelet index,coagulation function,fibrinolytic system and TCM syndrome score of the 2 groups were compared objectively.Results:The therapeutic effect of the observation group was better than that of the control group(P<0.05).The level of tumor markers in the observation group was significantly lower than that in the control group(P<0.05).There was no significant difference in platelet index level between the observation group and the control group(P>0.05).There was no significant statistic difference in coagulation function between the observation group and the control group.The improvement of fibrinolytic system indicators in the observation group was significantly better than that in the control group,with statistical difference(P<0.05); In addition,there were significant statistical differences in TCM syndrome scores between the 2 groups before and after treatment(P<0.05)in which the observation group showed the most significant improvement after treatment..Conclusion:Quyu Decoction combined with GP chemotherapy is effective in the treatment of advanced lung cancer with yin deficiency and endogenous heat.