To explore the efficacy of softening hardness, dissipating masses, invigorating blood and moving qi method in polycystic kidney disease patients at the stage of compensation period and decompensation period of renal insufficiency.Methods:A total of 150 patients of polycystic kidney disease with renal insufficiency treated in the Shijiazhuang Kidney Disease Hospital between June 2016 and June 2017 were selected as research objects.They were randomly divided into a control group and an observation group, with 75 patients in each group.The patients in the control group were treated with routine western medicine, and the patients in the observation group were additionally treated with softening hardness, dissipating masses, invigorating blood and moving qi method base on the treatment in the control group.The efficacy in the 2 groups was compared.Results:After the treatment, renal functional parameters like serum creatinine, uric acid and glomerular filtration rate in the control group were improved, and its kidney volume and the maximum cyst diameter were increased.In the observation group, the renal functional parameters like serum creatinine, uric acid and glomerular filtration rate were obviously improved, and the kidney volume and the maximum cyst diameter were decreased.The improvement in the observation group was greater than that in the control group, and the difference was statistically significant(P<0.05).There were interactions between treatment factors and time in all the items(P<0.05).The efficacy in the observation group was better than that in the control group, and the difference was statistically significant(Z=-5.685, P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the 2 groups(χ2=0.150, 0.694, 0.340, 1.027, 0.207 and 0.528, P>0.05).Conclusion:Treatment of polycystic kidney disease with renal insufficiency at the stage of compensation period and decompensation period by softening hardness, dissipating masses, invigorating blood and moving qi method can significantly improve the levels of serum creatinine, uric acid and glomerular filtration rate, hemoglobin, renal volume and maximum cyst diameter, and enhance the efficacy, which is worthy of clinical application.