To investigate the effect of Fuzheng Xiaoyu Decoction on blood lipid APN and blood flow in diabetic lower extremity arterial vascular lesions.Methods:A total of 100 patients with diabetic lower extremity vascular disease in Jingmen Second People's Hospital were selected from March 2015 to March 2016.According to the number of the patients' entrance number ID，the patients were randomly divided into a control group and an observation group.The control group was treated with routine treatment，and the observation group was treated with Fuzheng Xiaoyu Decoction on the basis of the control group.The curative effects of the 2 groups of patients after treatment，and the blood rheology and serum C reactive protein(CRP)，interleukin 6(IL-6)，tumor necrosis factor α(TNF-α)，blood lipid adiponectin(APN)，ankle brachial index，dorsal artery blood flow and adverse reactions of the 2 groups were compared and analyzed.Results:Before treatment，there was no significant difference in blood lipid APN between the 2 groups(P>0.05).After treatment，the serum lipid APN of the observation group was significantly higher than that of the control group，and the difference between the 2 groups was statistically significant(P<0.05).The total efficiency of the observation group(94%）was significantly lower than the control group(80%).Before treatment，the 2 groups had no statistically significant difference in low and high blood viscosity，plasma viscosity(P>0.05); after treatment，whole blood low and high viscosity and plasma viscosity was significantly lower than the control group，and CRP，IL-6，TNF-α level of these indicators before treatment were significantly lower than control group.There was significant difference between the 2 groups(P<0.05).Before treatment，there was no significant difference in the ankle brachial index and the blood flow rate of the dorsum of the foot between the 2 groups(P>0.05).After treatment，the ankle brachial index and the blood flow rate of the dorsum pedis artery of the observation group were significantly higher than those in the control group，and the difference between the 2 groups was statistically significant(P<0.05).Conclusion:The treatment of diabetic lower extremity vascular disease by Fuzheng Xiaoyu Decoction can improve the clinical efficacy，improve hemorheology and serum level，increased blood lipid APN level，reduce the incidence of adverse reactions，which is worthy of clinical application and promotion.