To investigate the regulation effect of Bailing Capsule combined with salvia miltiorrhiza polyphenolic acid on renal function and blood glucose in elderly patients with stage Ⅳ diabetic nephropathy.Methods:From January 2017 to January 2018,130 cases of elderly patients with stage Ⅳ diabetic nephropathy were selected in the Second Hospital of Huangshi.According to different treatment methods,they were randomly divided into an observation group and a control group.There were 65 cases in each group.The control group was treated with salvia miltiorrhiza polyphenolic acid alone and the experimental group was treated with Bailing Capsule combined with salvia miltiorrhiza polyphenolic acid.The changes of blood glucose and renal function were compared before and after the treatment for 4 weeks.Results:1)In the observation group,the renal function β2-MG(2.03±0.84)mmol/L,UPE(120.61±9.25)mg/d,Scr(220.56±12.18)μmol/L,BUN(2.42±0.69)mmol/L,UAER(325.13±12.08)mg/24 h were significantly lower than that of the control group(P<0.05); 2)In the observation group,Leptin(7.03±1.09)ng/mL,2 hPG(7.61±0.85)mmol/L,HbA1c(7.56±1.23)%,FPG(5.13±1.24)mmol/L were significantly lower than that of the control group and APN(15.22±2.16)mg/L was significantly higher than that of the control group(P<0.05); 3)There was no significant difference in the total adverse reaction rate between the observation group(7.69%)and the control group(9.23%)(P>0.05).Conclusion:For the elderly patients with stage Ⅳ diabetic nephropathy,combined therapy of traditional Chinese medicine and western medicine of Bailing Capsule combined with salvia miltiorrhiza polyphenolic acid can effectively control the blood glucose level of the patients,improve renal function indexes,and there are less toxic and side effects which has good clinical application value.