To study the effects of Danhong Injection combined with antimicrobial agents on serum MMP-2, MMP-9, TIMP-2, TIMP-1 and stress indexes after inguinal hernia surgery.Methods:From January 2015 to November 2017, 152 patients with strangulated hernia admitted in The First Affiliated Hospital of Hebei North University were analyzed retrospectively.According to different medications after the surgery, they were randomly divided into observation group(n=75)and control(n=77)group.After the inguinal hernia surgery, patients in the control group were given routine intravenously antibiotics.And patients in the observation group, we added Danhong Injection on the treatment basis of the control group.Changes of cortisol(Cor), norepinephrine(NE), aldosterone(ALD)and other stress indexes were recorded in the 2 groups, and changes of serum MMP-2, MMP-9, TIMP-2 and TIMP-1 levels were compared.Results:In the observation group, the stress indexes Cor, NE and ALD were significantly better than those in the control group.The serum levels of MMP-2, MMP-9, TIMP-2 and TIMP-1 in the observation group were statistically different compared to those in the control group(P<0.05).Conclusion:The efficacy of Danhong Injection combined with antimicrobial agents is remarkable for the postoperative recovery of inguinal hernia.When comparing to the use of antibiotics alone, the serum MMP-2, MMP-9, TIMP-2 and TIMP-1 levels, stress indexes and inflammatory factors are superior.It is worth of promoting in clinic.