To explore clinical efficacy of Wendan Decoction and Yuebi Decoction combined with mizolastine in the treatment of subacute eczema of spleen deficiency and dampness accumulation.Methods:A total of 90 patients with subacute eczema of spleen deficiency and dampness accumulation admitted in the Zhongshan Hospital of Traditional Chinese Medicine(TCM）from June 2016 to June 2017 were selected as research objects，and they were randomly divided into western medicine group，TCM group and combination group according to random number table method，with 30 cases in each group.Eczema area and severity index in the 3 groups were graded.The clinical effects of the three groups were compared.Patients who were effectively treated were followed up for 1 month to observe the recurrence and adverse drug reactions.Results:After the treatment，the symptom scores of erythema，papulovesicle，erosion and lichenification in the combination group and the western medicine group were significantly decreased(P<0.05)，and the symptoms of papulovesicle，erosion and lichenification in the TCM group were significantly improved(P<0.05).After 4 weeks of the treatment，the total effective rates in the 3 groups were statistically different(P<0.05).However，there was no statistical difference in the recurrence rate and the incidence of adverse drug reactions(P>0.05).Conclusion:There is good efficacy in patients with subacute eczema of spleen deficiency and dampness accumulation by using Wendan Decoction and Yuebi Decoction combined with mizolastine，which is worth clinical application.