To explore the effects of tenofovir dipivoxil combined with Shiwei Hezi Decoction Powder on liver function in patients with chronic hepatitis B(CHB)complicated with non-alcoholic fatty liver disease(NALFD).Methods:A total of 100 patients with CHB complicated with NALFD were selected from October 2017 to October 2018.They were divided into a control group(n=50)and an observation group(n=50)according to the random number table method.The control group was treated with tenofovir dipivoxil,while the observation group was treated with Shiwei Hezi Decoction Powder on the basis of the control group.Both groups were treated for 12 weeks.The liver function index,blood lipid index,liver ultrasonography and HBV-DNA load were compared before and after treatment in the 2 groups,and the adverse reactions were observed and compared in the 2 groups.Results:Compared with before treatment,the serum levels of TBIL,AST and ALT in the observation group after treatment were significantly lower than those in the control group,and the levels of ALB were significantly higher than those in the control group(P<0.01); Compared with before treatment,the serum levels of TG,TC and LDL-C in the observation group after treatment were significantly lower than those in the control group,and the levels of HDL-C in the observation group were significantly higher than those in the control group(P<0.01).Compared with before treatment,after treatment,the splenic vein diameter,portal vein diameter and spleen thickness in the observation group were significantly lower than those in the control group,and the right hepatic Vmax was significantly higher than that in the control group(P<0.01); compared with before treatment,the average HBV-DNA load in the observation group was significantly lower than that in the control group(P<0.05); after treatment,the total clinical effective rate of the observation group was 94.00%,significantly higher than that in the control group was 76.00%(P<0.05).There was no significant difference in the incidence of adverse reactions between the 2 groups(P>0.05).Conclusion:Shiwei Hezi Decoction Powder combined with tenofovir dipivoxil is effective in treating chronic hepatitis B complicated with non-alcoholic fatty liver disease,which can effectively improve the blood lipid level and liver function of patients.