To discuss the effects of Fuzheng Huayu Capsule on liver function and malonaldehyde(MDA)and matrix metalloproteinase-1(MMP-1)expression in patients with hepatitis B cirrhosis.Methods:From June 2014 to February 2016,148 patients with hepatitis B cirrhosis admitted in Chengdu Public Health Clinical Medical Center were divided into an observation group and a control group according to random number table,with 74 cases in each group.The control group was given adefovir dipivoxil tablet treatment,and the observation group was added Fuzheng Huayu capsule on the basis of the control group.And 2 groups were treated for 12 months continuously.The levels of liver function,liver fibrosis and MDA and MMP-1 were detected and compared before and after treatment,the clinical efficacy and HBV DNA negative conversion rate were recorded.Results:After treatment,the total effective rate of the observation group and the control group were 86.96%,68.57%,and the observation group was higher than the control group(P<0.05).The serum liver function indexes-levels of ALT,AST,TBIL and hepatitis fibrosis indexes-HA,PⅢNC,Col Ⅳ,LN in the 2 groups patients after treatment were significantly lower than before treatment and the observation group were lower than the control group(P<0.05 or P<0.01).Compared with before treatment,the serum MDA decreased and MMP-1 increased in the 2 groups patients(P<0.01),and there was apparent difference between the 2 groups(P<0.05 or P<0.01).After treatment,the serum HBV DNA negative conversion rate of the observation group and the control group were 94.20% and 90.00%,there was no significant difference between the 2 groups(P>0.05).Conclusion:Fuzheng Huayu Capsule combined with western medicine can significantly improve the liver function of patients with hepatitis B cirrhosis,reduce the expression of serum MDA,promote the expression of MMP-1,and reduce the degree of hepatic fibrosis.