To evaluate the clinical effect of Banxia Baizhu Tianma Decoction on vertigo after stroke,and observe its effect on plasma neuropeptide Y(NPY)and plasma endothelin 1(ET-1)concentration.Methods:From January 2015 to January 2016,60 cases of vertigo after wind phlegm obstructing the collaterals treated by Yanan University Affiliated Hospital were divided into a control group and an observation group,with 30 cases in each group.Two groups of patients received conventional medical treatment of stroke,in addition to that,the control group was treated by betahistine and Flunarizine Capsules.On the basis of the control group,the observation group was treated with Banxia Baizhu Tianma Decoction,200 mL,taken separately in morning and evening along with warm water.The two groups were treated for 15 days and the clinical efficiency,Fugl-Meyer motor function scale and WOLF motor ability test scale(WOLF)score,Berg balance scale(BBS)and functional independence score(FIM)changes were compared between the 2 groups.At the same time,changes of peripheral blood NPY and ET-1 concentration were detected before and after treatment.Results:The total efficiency of the observation group was 87%,control group was 66% and there was significant difference between the 2 groups(χ2=2.89,P<0.05); Before the treatment the dizziness handicap scale(DHI),Fugl-Meyer score,WOLF score,BBS score,FIM,SF-36 score,DHI score and peripheral blood NPY and ET-1 showed no significant difference(P>0.05).After treatment,DHI score in the 2 groups decreased,and the observation group decrease trend was more significantly(P<0.05); Two groups of Fugl-Meyer score,WOLF score and BBS score were higher than that of before the treatment(P<0.05),and the observation scores were better than the control group(P<0.05); The ability of daily life of the 2 groups of patients after treatment was better than that of before the treatment(P<0.05)and the observation group improved more significantly compared with the control group(P<0.05); DHI score and the concentration of NPY and ET-1 in the peripheral blood of the 2 groups decreased(P<0.05),and NPY and ET-1 levels had a positive correlation.Conclusion:Banxia Baizhu Tianma Decoction has an ideal effect on wind phlegm obstructing vertigo,and its mechanism may be related to the decreased expression of NPY and ET-1.