To explore clinical efficacy of Huatan Kaibi Decoction in coronary heart disease(CHD）with cardiac insufficiency(turbid phlegm obstruction syndrome).Methods:A total of 60 CHD patients with cardiac function Ⅱ-Ⅳ grade admitted in the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine from January 2017 to October 2017 were selected as research objects，and they were randomly divided into control group and observation group，with 30 patients in each group.The control group was treated with routine western medicine.The observation group was treated with Huatan Kaibi Decoction on the treatment basis of the control group.Changes of cardiac functional grading，brain natriuretic peptide(BNP）level，left ventricular ejection fraction(LVEF)，left ventricular end-systolic dimension(LVSD)，left ventricular end-diastolic dimension(LVDD）and quality of life improvement score were compared between the 2 groups before and after the treatment.Results:From the aspect of cardiac functional grading，the total effective rate in the observation group was 90%，while that in the control group was 76.67%，with no statistical difference between the 2 groups.In the 2 groups after the treatment，the BNP level was significantly decreased，the LVEF was increased，and the LVSD，LVDD and quality of life improvement score were decreased.But those in the observation group were better than those in the control group，and the difference was statistically significant.Conclusion:Huatan Kaibi Decoction can improve the cardiac function in CHD patients with chronic cardiac insufficiency(turbid phlegm obstruction syndrome)，and improve patients' quality of life，with safety and reliability.So，it is worthy of further study.