To explore the clinical study on Yishen Xiezhuo Method in the treatment of advanced diabetic nephropathy(DN)through the regulation of oxidative stress.Methods:A total of 120 patients with advanced diabetic nephropathy admitted to Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from June 2015 to June 2018 were selected.They were divided into a control group(n=60)and an observation group(n=60)according to random number table method.The control group was given routine symptomatic treatment of western medicine,while the observation group was given the treatment of Yishen Xiezhuo Method on this basis.The changes of renal function,inflammatory reaction and oxidative stress were recorded before and after treatment,and the clinical efficacy of the 2 groups was observed.Results:After treatment,the levels of UTP,β2-MG,SCr,CRP,TNF-α,IL-6,MDA and AOPPs in the observation group were significantly lower than those before treatment and in the control group(P<0.01),while the levels of SOD were significantly higher than those before treatment and in the control group(P<0.01),and the total clinical effective rate in the observation group was significantly higher than that in the control group(P<0.01).Conclusion:Yishen Xiezhuo Method can significantly reduce the inflammatory reaction and the production of oxidative stress products in patients with advanced DN,enhance the ability of anti-oxidative stress,improve renal function,alleviate clinical symptoms,and improve the clinical total effective rate.