To explore the clinical effect of Weisu Granules combined with quadruple therapy in the treatment of Helicobacter pylori(Hp)-related peptic ulcer(PU)and its influence on the level of inflammatory factors.Methods:A total of 250 cases of Hp-related PU patients treated in our hospital from July 2016 to April 2018 were divided into a control group(n=125)and an observation group(n=125)according to random number table method.The control group was given quadruple therapy,and the observation group was given Weisu Granules treatment on this basis.The clinical efficacy,Hp eradication rate,ulcer healing rate,recurrence rate within one year and adverse reaction rate of the 2 groups after treatment were counted of 2 groups,and the differences of inflammatory factor levels between the 2 groups before and after treatment were compared.Results:After treatment,the total clinical effective rates of the observation group and the control group were 92.00% and 83.23%.The observation group was significantly higher than the control group(P<0.05); Compared with before treatment,the levels of hs-CRP and PCT in the two groups were remarkably lower after treatment,and those in the observation group were significantly lower than those in the control group(P<0.01).After treatment,the eradication rates of HP in the observation group and the control group were 92.00% and 83.20%,the healing rates of ulcers were 84.00% and 73.60%.The observation group was higher than the control group(P<0.05).The recurrence rates of 1 year in the observation group were 12.80% and 23.20% respectively,which were prominently higher than those in the control group(P<0.05),and the recurrence rates in the observation group were apparently lower than those in the control group(P<0.05).The incidence of adverse reactions in the observation group and the control group were 16.80% and 27.20%.The incidence of adverse reactions in the observation group was remarkably lower than that in the control group(P<0.05).Conclusion:Weisu Granules combined with quadruple therapy for Hp-related PU can effectively alleviate clinical symptoms and reduce the level of inflammatory factors,which is better than western medicine alone,and is worthy of clinical promotion and application.