To observe the efficacy of Dingxuan Zhitong Paste in treating patients with senile hypertension of yin deficiency resulting in effulgent fire syndrome.Methods:From July 2016 to June 2017，153 cases with senile hypertension of yin deficiency resulting in effulgent fire syndrome admitted in the Affiliated Hospital of Shaanxi University of Chinese Medicine were selected as research objects and analyzed retrospectively.According to different drug therapies，they were randomly divided into control group(n＝76）and observation group(n＝77).The observation group was treated with Dingxuan Zhitong Paste and Compound Kendir Leaves Tablets，while the control group was treated with the Compound Kendir Leaves Tablets alone.Changes of related indexes in the patients and clinical efficacy during the treatment were observed.Results:1）The changes of blood glucose and blood lipid：In the observation group after the treatment，FPG(4.57±0.42）mmol/L and 2 hFBC(6.04±0.73）mmol/L.In the control group after the treatment，FPG(6.53±0.68）mmol/L and 2 hFBC(9.85±0.96）mmol/L.In the observation group after the treatment，HDL-C(1.84±0.36）mmol/L，TC(4.39±0.82）mmol/L，TG(1.14±0.47）mmol/L and LDL-C(1.86±0.28）mmol/L.After the treatment in the control group，HDL-C(1.29±0.30）mmol/L，TC(5.88±1.17）mmol/L，TG(1.88±0.84）mmol/L and LDL-C(2.49±0.35）mmol/L. 2）Hemorheology：After the treatment，the hemorheological indexes of patients were decreased.The whole blood high shear viscosity(5.22±0.57）mPa·s，whole blood low shear viscosity(10.24±1.09）mPa·s，plasma specific viscosity(1.44±0.26）mPa·s and fibrinogen(3.03±0.26）g/L in the observation group were significantly superior to those in the control group. 3）Syndrome integral of yin deficiency resulting in effulgent fire in traditional Chinese medicine(TCM)：The total integral in the observation group was decreased from(15.41±0.36）to(3.31±0.22)，that in the control group was decreased from(15.29±0.43）to(6.79±0.25). 4）Blood pressure changes：In the observation group after the treatment，systolic pressure(121.44±4.14）mmHg，diastolic pressure(81.26±3.18）mmHg and pulse pressure(37.94±1.21）mmHg were significantly decreased.The circadian rhythm of systolic pressure(7.14±1.86)% and the circadian rhythm of diastolic pressure(9.46±2.88)% were increased significantly.The improvement of indexes was better than that in the control group.Conclusion:For the treatment in patients with senile hypertension of yin deficiency resulting in effulgent fire syndrome，Dingxuan Zhitong Paste combined with Compound Kendir Leaves Tablets has significant efficacy.It can promote recovery of blood glucose and blood lipid levels and decrease hemorheology indexes，thus improving blood pressure symptoms of the patients.