To discuss the clinical effect of sequential therapy of integrated Yougui Pills and acupuncture and moxibustion on the treatment of premature ovarian failure and its effect on ovarian function,ovarian hemodynamics and sex hormone levels.Methods:From March 2017 to September 2018,126 cases of premature ovarian failure patients admitted to Liaocheng People's Hospital were selected as the research objects,and were divided into a control group and an observation group,with 63 cases in each group by random number table method.Patients in the control group were given sequential therapy,while patients in the treatment group were treated with Yougui Pills and acupuncture on the basis of control therapy.The clinical effects were compared by observing the 2 groups of traditional Chinese medicine syndrome scores before and after treatment.The perimenopausal symptoms were evaluated by the modified Kupperman index,and the changes of ovarian function,ovarian hemodynamic index and sex hormone level were detected before and after treatment.Results:The effective rate of the treatment group was 90.48%,which was significantly higher than that of the control group of 77.78%(P<0.05).After treatment,the clinical symptoms of patients in the treatment group were significantly improved than those in the control group.The traditional Chinese medicine syndrome scores and Kupperman scores were significantly lower than those in the control group,and the improvement of ovarian function was higher than those in the control group.The AFC,OAV and MOD of ovarian function indicators were all significantly higher than those in the control group(P<0.05); The ovarian hemodynamic indexes PI and RI were significantly lower than those of the control group,and the PSV level significantly increased(P<0.05).The levels of hormone E2 were significantly higher than those of the control group,and the FSH and LH level were significantly lower than those of the control group(P<0.05).Conclusion:Sequential therapy of integrated Yougui Pills,acupuncture and moxibustion are beneficial to alleviate the clinical symptoms of patients with premature ovarian failure,improve ovarian reserve function,promote local microcirculation of the ovary,and effectively regulate the level of endocrine hormones,which are worthy of clinical promotion and application.