To study the curative efficacy of of wrist-ankle acupuncture combined with mecobalamin on ischemic stroke combined with hemisensory impairment and its effect onsomatosensory evoked potential,cerebral hemodynamics and quality of life.Methods:The patients with ischemic stroke complicated with hemiparesis admitted to our hospital from Sep 2014 to Jun 2018 were randomly divided into two groups:the control group treated with mecobalamin and the observation group treated with wrist-ankle acupuncture combined with mecobalamin.The differences of sensory impairment score,TCM syndrome score,somatosensory evoked potential,cerebral hemodynamics index and quality of life between the two groups before and after treatment were compared.Results:After treatment,sensory disturbance score,peak amplitude of median nerve and tibial nerve,cerebral blood flow amplitude and inflow volume velocity,SS-QOL score were significantly increased in both groups,while the scores of TCM syndromes were significantly decreased(P<0.05).After treatment,sensory disturbance score,peak amplitude of median nerve and tibial nerve,cerebral blood flow amplitude and inflow volume velocity,SS-QOL score in the observation group were significantly lower than those of control group,while the scores of TCM syndromes were significantly lower than that of the control group(P<0.05).Conclusion:Wrist-ankle acupuncture combined with Mecobalamin in the treatment of hemisensory disorders complicated with ischemic stroke can improve the curative effect,somatosensory evoked potential,cerebral hemodynamics and quality of life,and has positive clinical therapeutic value.