Guided by the principle of syndrome differentiation and treatment in the Treatise on Cold Damage，this paper proposes a computer model design that simulates doctors' thinking of syndrome differentiation and treatment.The model design is based on Neo4j's graph data construction technology，Cypher language's graph pattern matching technology and Jaccard's similarity formula，aiming at analyzing and reasoning the input symptoms to clarify the diagnosis and differential diagnosis results of the disease and syndrome，and to give the corresponding therapeutic formula.It simulates the syndrome differentiation and treatment of “watching the pulse and syndrome，knowing the problem，and treating it based on the syndrome” in the Treatise on Cold Damage，in order to provide reference and enlightenment for the modeling of clinical assistant diagnosis and treatment in traditional Chinese medicine.