To explore the potential molecular mechanism of safflower treatment of coronary heart disease based on integrated pharmacology.Methods:Using “Safflower” and “Coronary heart disease” as the qualifiers,this study explores the active constituents of safflower and their related targets based on the integrated pharmacology platform.It also explores the potential targets of CHD and analyzes its related signal pathways.This study constructs the “Chinese medicine ingredient target” in order to explore the potential molecular mechanism of safflower treatment of CHD from multiple perspectives.Results:It was found that the intervention of safflower to CHD may be related to a variety of compounds,mainly in red and yellow pigments and polyphenols.From the key target and action pathway,it can be seen that safflower CHD is mainly used in COX7C,COX5A,GCK,ATP5A1 and COX5B genes,including the signal pathways such as energy metabolism,oxidative phosphorylation and circulatory system.Conclusion:The safflower plays a role in the treatment of CHD through multi-molecule,multi-target and multi-signal pathways,and provides a theoretical basis for further systematic research and clinical application as well as providing a certain reference value for the development of new drugs.