To observe effects of modified Erbu Zhuyu Formula on endometrial receptivity in patients with repeated IVF-ET failure.Methods:Data of multicenter patients with repeated IVF-ET failure from January 2016 to March 2018 were collected.After 3 months of intervention with modified Erbu Zhuyu Formula，it was compared with non-intervention group.Endometria of patients in the 2 groups were collected during mid-luteal phase for biopsy and they were studied and observed from the perspective of molecular biology.Expression of HOXA10 mRNA was studied by qPCR.Immunohistochemistry was used to detect indexes such as LIF and integrin ανβ3.Pregnancy outcomes were collected.Results:There was obvious difference between the 2 groups in the expression of HOXA mRNA(P<0.05).There were obvious differences between the 2 groups in the expressions of LIF and integrin ανβ3(P<0.05).The embryo implantation rate and clinical pregnancy rate were increased significantly(P<0.05).Conclusion:Modified Erbu Zhuyu Formula can improve the expressions of endometrial HOXA10 mRNA，LIF and integrin ανβ3 within mid-luteal phase in patients with repeated IVF-ET failure.Its efficacy should be affirmed that modified Erbu Zhuyu Formula can improve the endometrial receptivity in patients with repeated IVF-ET failure.