To evaluate effects of Chinese patent medicine-Wenxin Granules compound on myocardial electrophysiological remodeling after myocardial ischemia by the method of systematic review.Methods:Academic papers from journals in CNKI，CBM，Wanfang，VIP，EBbase，Pubmed，Cochrane and Web of science databases were searched by using Chinese and English search terms of “Wenxin” as subject words，and animal experimental studies meeting inclusion and exclusion criteria were screened out.An assessment tool of bias risk in animal experiment-SYRCLE was applied to evaluate quality of literature and analyze outcome indicators.Results:A total of 7 papers on effective animal experiment were included.After the evaluation，it was found that their quality was relatively low.The main outcome indicators were ECG，gap junction structure，gap junction protein and its mRNA，CaM/CaMKII signaling pathway related proteins，related mi-RNAs and action potential of cardiomyocytes.Due to the lack of specific values and quantification of outcome indicators in the included studies，descriptive systematic review was used for summative evaluation of outcome indicators.Conclusion:Wenxin Granules can improve different types of arrhythmia and make it intuitively reflected on the electrocardiogram.At the same time，it can improve the ultrastructure of gap junction，change expression levels of the gap junction protein and its mRNA，the CaM/CaMKII signaling pathway related proteins，and the related mi-RNAs，and regulate cardiomyocyte ion channels to maintain normal cardiomyocyte action potentials，thereby improving the electrophysiological remodeling of ischemic myocardium in rats.However，the quality of studies included in the evaluation is relatively low，which requires further exploration of relevant mechanism by high-quality experimental studies with better methodology.