To study the main active ingredients，targets and pharmacological mechanism of “Rhizoma Ligustici Chuanxiong-Rhizoma Corydalis” drug pair based on network pharmacology.Methods:The chemical components and targets related to Rhizoma Ligustici Chuanxiong-Rhizoma Corydalis were researched from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)according to oral bioavailability(OB)and drug likeness(DL).Cytoscape 3.6.0 software was used to build the active ingredient-target network model and screen for core targets.The GO and KEGG pathways in the targets were analyzed by DAVID.Results:58 active components were screened from “Rhizoma Ligustici Chuanxiong-Rhizoma Corydalis” drug pair，involving 220 related action targets.It mainly involved multiple signaling pathways such as cancer，signal transduction，immunity，cell communication and apoptosis signaling pathways.Conclusion:This paper preliminarily revealed the main active ingredients，targets and synergistic mechanism of the herbal pair of “Rhizoma Ligustici Chuanxiong-Rhizoma Corydalis”，providing a reference for further exploration of its pharmacological effects.