Systematic pharmacology(TCMSP)is used to analyze the basic theory of traditional Chinese medicine，aiming to understand the connotation of basic theory of Chinese medicine and the application of TCMSP.Methods:The research on TCMSP and its application in the basic theory of traditional Chinese medicine was carried out，and representative research cases were cited for analysis.Results:The basic theory of traditional Chinese medicine had a long history and was especially important in traditional Chinese medicine.It was especially important to carry out comprehensive and evidentiary interpretation.Conclusion:The theory of TCM and its system as a whole cannot be studied from a certain point or a certain aspect.TCMSP is a molecular mechanism for studying TCM from a holistic and systematic perspective，which can explain the basic theories of modern medicine in complex Chinese medicine.