To compare and analyze clinical efficacy of Chaiyin Oral Liquid and oseltamivir in the treatment of children upper respiratory tract infection.Methods:A total of 80 cases of children with upper respiratory tract infection admitted in Tongzhou Maternal & Child Health Hospital of Beijing from December 2016 to December 2018 were selected as subjects and divided into observation group and control group according to random number table method，with 40 patients in each group.The observation group was given Chaiyin Oral Liquid，and the control group was given oseltamivir.They were treated for 7 d.The clinical efficacy and level changes of T lymphocyte subsets(CD3+，CD4+ and CD8+)in the 2 groups were observed.Meanwhile，cough disappearance time，fever recession time，throat congestion disappearance time and incidence of adverse reactions in the 2 groups were recorded and compared.Results:After the treatment，the total effective rate in the observation group reached 92.5%(37/40)，and the total effective rate in the control group reached 87.5%(34/40).The total effective rate in the observation group was higher than that in the control group，and the difference between the 2 groups was not statistically significant(P>0.05).After the treatment，the levels of CD3+ and CD4+ in the 2 groups were increased to different degrees，and the levels in the observation group were higher than those in the control group，while the levels of CD8+ were decreased.The comparison before the treatment in the 2 groups was not statistically significant(P>0.05)，while the difference after the treatment was statistically significant(P<0.05).The disappearance time of cough and fever in the observation group was lower than that in the control group，and the disappearance time of throat congestion was higher than that in the control group.There was no statistically significant difference between the 2 groups(P>0.05).The incidence of adverse reactions in the observation group was only 5%，while that in the control group was up to 15%.Conclusion:Chaiyin Oral Liquid is similar to oseltamivir in the clinical sign disappearance time，and its clinical total effective rate is higher than that of oseltamivir.It has a significant effect in the recovery of immune function and a low incidence of adverse reactions，so it has more clinical application value.