To study and observe clinical efficacy of surgery combined with Jianpi Shengxue Tablets in the treatment of mixed hemorrhoids with anemia patients and to analyze its safety.Methods:A total of 92 patients with mixed hemorrhoids and anemia admitted in Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University from July 2017 to July 2019 were selected as subjects.They were divided into observation group and control group according to random number table method，with 46 cases in each group.The 2 groups of patients were treated with FOCUS ultrasound knife surgery.The control group was treated with Shengxuebao Mixture after the surgery，while the observation group was treated with Jianpi Shengxue Tablets after the surgery.After 3 months of continuous treatment，the clinical efficacy，syndrome score changes in traditional Chinese medicine(TCM)，blood test indicators and the incidence of adverse reactions in the 2 groups were statistically compared.Results:The total effective rate in the observation group was 97.83%(45/46)，which was higher than that in the control group 19.57%(9/46)，and the difference was statistically significant(P<0.05).Before the treatment，there was no significant difference in the TCM syndrome scores between the 2 groups(P>0.05).After the treatment，the TCM syndrome scores in the 2 groups were decreased significantly，and the scores in the observation group were significantly lower than those in the control group(P<0.05).There was no significant difference in the levels of RBC，Hb，HCT，MCV and SF between the 2 groups before the treatment(P>0.05).After 1，2 and 3 months of the treatment，the levels of RBC，Hb，HCT，MCV and SF in the observation group were higher than those in the control group，and the difference was statistically significant(P<0.05).The incidence of adverse reactions was 4.35%(2/46)in the observation group and 8.70%(4/46)in the control group，with no significant difference(P>0.05).Conclusion:Jianpi Shengxue Tablets combined with FOCUS ultrasound knife surgery is significantly effective in treating mixed hemorrhoids with anemia patients.It can improve relevant TCM syndrome and blood routine indicators，and the incidence of adverse reactions is low.The treatment is safe and worthy of clinical recommendation.