To investigate the effects of Yiqi Fuming Decoction combined with photodynamic therapy on age-related macular degeneration(AMD)，and to evaluate the changes of immune inflammation and oxidative stress.Methods:A total of 181 patients with AMD underwent treatment in Xi'an Hospital of Traditional Chinese Medicine during September 2015 to February 2018 were chosen as research subject.The treatment plans were retrospectively analyzed，and all patients were divided into a control group(n＝95，treated with photodynamic therapy）and an observation group(n＝86，treated with Yiqi Fuming Decoction combined with photodynamic therapy).The short-term curative effect，difference of serum immune inflammation，oxidative stress indexes between the 2 groups after treatment were compared.Results:After treatment，the effective rate of the observation group was higher than that of the control group(P<0.05).Proportion of Treg in peripheral blood in the observation group was higher than that of the control group，and proportion of Th17 was lower than that of control group; serum contents of inflammatory factors such as IL-1，IL-6 and TNF-α in the observation group were lower than that in the control group; serum contents of oxidative stress indexes such as ROS，MDA were lower than those in the control group; serum contents of CAT and GSH-Px were higher than those in the control group(P<0.05).There were no significant difference in the incidence of adverse drug reactions between the 2 groups(P>0.05).Conclusion:Adding Yiqi Fuming Decoction to AMD patients on the basis of photodynamic therapy can further enhance the therapeutic effect，and optimize the microenvironment of immune inflammation and oxidative stress，which is of great significance to final good treatment outcome.