To explore the effects on IL-27,hsCRP and NT-proBNP in patients with chronic heart failure(CHF)of yang deficiency and edema type using Wenyang Qiangxin Decociton.Methods:A total of 80 patients with CHF of yang deficiency and edema type from The First Affiliated Hospital of Heilongjiang University of Chinese Medicine were randomly divided into an observation group and a control group according to the order of admission,with 40 cases in each group.The control group used conventional treatment options such as improving heart function,dilating cardiovascular,promoting water and diuresis,while the observation group was added with self-made Wenyang Qiangxin Decoction.Both groups were treated with 4 weeks.The levels of IL-27,hsCRP,NT-proBNP,the scores of TCM syndromes and the total effective rates were compared between the 2 groups,and their correlation was calculated and analyzed.Results:After treatment,the total effective rate in the observation group was 92.50 %,which was significantly higher than 72.50% of the control group(P<0.05).After treatment,the scores of TCM syndromes in the 2 groups decreased significantly(P<0.05),and there was significant difference between the 2 groups(P<0.05).After treatment,the levels of hsCRP and NT-proBNP in the observation group were lower than those in the control group(P<0.05),while the level of IL-27 in the observation group was higher than that in the control group(P<0.05).IL-27 was negatively correlated with hsCRP and NT-proBNP,and the correlation was statistically significant(P<0.05).Conclusion:The Wenyang Qiangxin Decoction has an obvious curative effects on CHF of yang deficiency and edema type,and it can effectively improve the heart function,which is worthy for further clinical application.