To explore the efficacy of Yiqi Huoxue Huxin Prescription on coronary heart disease angina pectoris and its influence on cardiac function and vascular endothelial growth factor(VEGF).Methods:A total of 94 cases of coronary heart disease angina pectoris patients were selected and randomly divided into an observation group and a control group,with 47 cases in each group.The control group was treated with conventional western medicine,and the observation group added Yiqi Huoxue Huxin Prescription on the basis of control group.The clinical efficacy of 2 groups after treatment for 2 months were compared,and the improvement of main clinical symptoms,the serum VEGF level and cardiac function were compared in the 2 groups before and after treatment.Results:The total effective rate of the observation group was 89.36%,which was significantly higher than 72.34% of the control group(P<0.05).After treatment,the clinical symptoms scores of the 2 groups significantly decreased,and the observation group was significantly lower than that of the control group(P<0.01).Compared with before treatment,the serum VEGF level and cardiac function index CO,LVEF of the 2 groups significantly increased,TFC,SVR significantly decreased,and there was significant difference between the 2 groups(P<0.05 or P<0.01).Conclusion:Conventional western medicine add to Yiqi Huoxue Huxin Prescription can improve the clinical symptoms of patients with coronary heart disease angina pectoris,increase the serum VEGF level,improve the cardiac function of patients and overall clinical efficacy,improve the prognosis of patients.