To explore the therapeutic effect of warming meridians and opening depression on chronic hepatitis B(CHB).Methods:A total of 26 CHB patients hospitalized in Guangdong Integrated Traditional Chinese and Western Medicine from June 2016 to January 2019 were randomly divided into a control group(13 cases)and an observation group(13 cases)according to the order of visit.The control group was treated with entecavir,while the observation group was treated with Wenjing Kaiyu Granules on the basis of the control group for 24 weeks.Lymphocyte subsets,alanine aminotransferase(ALT),aspartate aminotransferase(AST),ALT/AST,glutamyltransferase(GGT),hyaluronidase(HA),laminin(LN),procollagen type III N-terminal peptide(P III NP),collagen type IV(C IV)were observed before and after treatment.The changes of chronic liver disease questionnaire(CLDQ)scores were compared and evaluated after treatment.Results:1）There was no significant difference in CD4+,CD8+,CD4+/CD8+ in the control group before and after treatment(P>0.05).After treatment,CD4+,CD4+/CD8+ in the observation group increased significantly,while CD8+ decreased significantly(P<0.05).After treatment,CD4+,CD4+/CD8+ in the observation group was significantly higher than that in the control group,and CD8+ in the observation group was significantly lower than that in the control group(P<0.05).2)After treatment,ALT,AST,ALT/AST,GGT and in the 2 groups were significantly lower than those before treatment(P<0.05),and the above indexes in the 2 groups were significantly lower than those in the control group(P<0.05).3)After treatment,HA,LN,P III NP,C IV and HBV-DNA in the 2 groups decreased significantly compared with those before treatment(P<0.05),and the above indexes in the observation group were significantly lower than those in the control group(P<0.05).4)The scores of abdominal symptoms,sleepiness,systemic symptoms,activity ability,emotion and anxiety in the 2 groups after treatment were significantly increased than those before treatment(P<0.05),and those in the observation group after treatment were significantly higher than those in the control group(P<0.05).After the completion of treatment,the marked efficiency and total efficiency of the observation group were significantly higher than those of the control group,and the difference was statistically significant(P<0.05).Conclusion:Warming meridians and opening depression method can improve CHB immune function,liver function and liver fibrosis,and improve the quality of life.