To observe the efficacy and safety of Bushen Tiaogan Shengjing Decoction in the treatment of idiopathic asthenospermia of kidney-deficiency and liver-depression syndrome.Methods:A total of 66 patients with idiopathic asthenospermia of kidney-deficiency and liver-depression syndrome in Xiyuan Hospital，China Academy of Chinese Medical Sciences from June to November 2016 were randomly divided into a control group and an observation group according to random number table，with 33 cases in each group.The control group was given Levocarnitine Oral Solution，1 bottle at a time，3 times a day.The observation group was given Bushen Tiaogan Shengjing Decoction，1 dose per day，1 bag each morning and evening.The clinical efficacy was evaluated after 12 weeks of continuous treatment in both groups.The sperm motility(PR，PR+NP)and TCM symptom scores were compared before and after the treatment，and the safety of the medicine was observed.Results:By comparing the 2 groups after treatments，it was found that there was no statistically significant difference between the 2 groups in improving the PR，PR+NP sperm at the 4th and 8th week of treatment(P>0.05).owever，a significant difference was found in the improvement of PR，PR+NP sperm at the 12th week of treatment(P<0.05)，and the observation group was more effective.The scores of TCM symptoms were better than before，and the observation group was better than the control group(P<0.05).No significant adverse reactions occurred in either group.Conclusion:The observation group is better than the control group in improving the sperm motility rate，the quality of semen，and TCM symptoms(P<0.05)，indicating that Bushen Tiaogan Shengjing Decoction has better curative effects in treating kidney-deficiency and liver-depression syndrome of idiopathic asthenospermia and it is worthy of clinical application.