To evaluate the clinical effect of drug separated moxibustion in treating dysmenorrhea caused by endometriosis.Methods:A total of 96 patients with dysmenorrhea caused by endometriosis treated in Qingdao Traditional Chinese Medicine Hospital from March 2017 to June 2018 were selected and divided into a control group and an observation group according to random number table，with 48 cases in each group.The control group was given conventional drug treatment，and the observation group added drug separated moxibustion.The relief of dysmenorrhea，improvement of related clinical indicators and occurrence of adverse reactions were observed.Results:During the first，second，third month period of treatment，the dysmenorrhea and duration CMSS scores of the observation group were significantly lower than those before treatment(F=13.415，11.941，P<0.05)，and were significantly lower than the control group(P<0.05); The levels of CA125，IL-8 and PGF2α，OT in the observation group were significantly lower than those in the control group after treatment(t=4.256，3.755，6.344，4.248，P<0.05); The pelvic mass of the observation group after treatment was significantly smaller than that of the control group(t=22.912，P<0.05); The total incidence of adverse reactions was 4.17%，significantly lower than 16.67% of the control group(χ2=4.018，P<0.05).Conclusion:Drug separated medication for moxibustion in patients with dysmenorrhea due to endometriosis is helpful to reduce pelvic mass，improve the relief effect of dysmenorrhea，reduce adverse reactions，and the overall effect is more accurate.