To explore the effects of Wuwei Xiaodu Decoction combined with acupuncture at Xialao(BL34)and Jiaoxin(KI8)points on inflammatory cytokines and T lymphocyte subsets in patients with acute pelvic inflammatory disease(APID).Methods:A total of 103 patients with APID in Huaibei Hospital of Traditional Chinese Medicine from January 2016 to June 2018 were randomly divided into a control group(n＝51)and an observation group(n＝52).Patients in the control group were given conventional treatment,and the observation group was treated with Wuwei Xiaodu Decoction combined with acupuncture at Xialao(BL34)and Jiaoxin(KI8)points on the basis of the control group.The clinical efficacy of the 2 groups were evaluated and compared.The recovery time of abdominal pain,body temperature,white blood cell count(WBC)and neutrophil ratio(NEUT)were compared between the 2 groups.The TCM symptom score,WBC,NEUT,serum interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),procalcitonin(PCT)levels and peripheral blood CD3+,CD4+,CD8+ levels were compared between the 2 groups before and after treatment.The occurrence of adverse reactions during the treatment was recorded.Results:The clinical efficacy rate of the observation group was 94.23%(49/52),which was significantly higher than 80.39%(41/51)of the control group(P<0.05).The scores of main symptoms and minor symptoms in the observation group after treatment were significantly lower than those in the control group(P<0.05).The abdominal pain disappear time,body temperature recovery time,WBC recovery time and NEUT recovery time of the observation group were significantly shorter than those of the control group(P<0.05).The levels of serum IL-6,CRP,TNF-α,PCT,WBC,NEUT and CD8+ in the observation group after treatment were significantly lower than those in the control group(P<0.05).The peripheral blood CD3+,CD4+ levels were significantly higher than those in the control group(P<0.05).There was no adverse reaction of the 2 groups during treatment.Conclusion:Wuwei Xiaodu Decoction combined with acupuncture at Xialao(BL34)and Jiaoxin(KI8)points in treatment of APID curative effect is significant.It can significantly improve clinical symptoms,reduce inflammatory cytokine levels,improve immune function,and has good safety.