Heart failure(HF)is the end stage of various cardiovascular diseases.In recent years，with the increase in the incidence of cardiovascular diseases such as hypertension and coronary heart disease，the number of people eventually developing into heart failure has gradually increased.Oxidative stress(OS)refers to the imbalance of oxidation and anti-oxidation in the body，leading to inflammatory infiltration of neutrophils，increase of proteases secretion，and production of a large number of oxidative intermediates，which has a negative effect on the body.Huge amount of studies have shown that oxidative stress plays an important role in occurrence and development of heart failure.This paper aims to explore the mechanism of oxidative stress in heart failure and provide new ideas and research directions for prophylaxis and treatment of heart failure.