To optimize the extraction process of Jiedu Zhixue Granules. Methods:Taking the baicaline, wogonoside, paeonol content and dry extract yield as the evaluation index, the extraction process of Jiedu Zhixue Granule was researched by using the combination methods between orthogonal test and BP artificial neural network to study the influence of water addition, extraction time, extraction times etc., and using the analytic hierarchy process (AHP) to weighted mark comprehensively for screening extraction process of Jiedu Zhixue Granule. Results:The optimum extraction process was as following: adding 11 times the amount of water, heating reflux extraction 3 times, and each time for 105 minutes. Conclusion:The optimal extraction process is scientific, rational, stable and feasible. The optimization method of orthogonal experiment combined with BP artificial neural network is suitable for R&D needs of TCM preparation in medical institution because of its practical and efficient characteristics.