To investigate the effects of Jiawei Shentong Zhuyu Decoction on osteoporosis model rats，and to observe its effects on biomechanics and bone metabolism.Methods:A total of 80 female Wistar rats were randomly divided into a blank group(10 rats)and a model group(70 rats).All rats in model group received hysterectomy to simulate osteoporosis.60 successfully modeling rats were randomly divided into a placebo group，a control group，a low-dose group，a medium-dose group and a high-dose group，with 15 rats in each group.The rats in the traditional Chinese medicine group were given modified Shentong Zhuyu Decoction by gavage，with the high-dose group(1.32 g/mL)，the medium-dose group(0.66 g/mL)and the low-dose group(0.33 g/mL)，once a day for 3 weeks; the rats in the placebo group were given saline by gavage，10 mL/time，once a day for 3 weeks; the rats in the control group were given calcitonin injection，twice a week，for 3 weeks.After 3 weeks，bone biomechanical data，mineral density and trabecular structure of right tibia，serum osteocalcin and serum type I collagen telopeptide(PINP)were measured.Results:Compared with the blank group，the modulus of elasticity and the maximum load of the model group were decreased(P<0.05).Compared with the placebo group，the modulus of elasticity and the maximum load of the control group and the traditional Chinese medicine group increased significantly(P<0.01).With the increase of dose，the elastic modulus and maximum load of the rats in the traditional Chinese medicine group increased significantly(P<0.05).2)Compared with the blank group，BMD，BV/TV，Tb.N and Tb.Th in the model group decreased(P<0.05); BMD in the control group and the traditional Chinese medicine group increased significantly(P<0.01); BMD in the middle-dose group and the high-dose group increased significantly(P<0.05).3)Compared with the blank group，the serum BGP and P INP levels in the model group were significantly increased，and the difference was statistically significant(P<0.05).Compared with the model group，the serum BGP and P INP in the traditional Chinese medicine group were significantly decreased.With the concentration of modified Shentong Zhuyu Decoction increasing，the trend of BGP and PINP declining was more obvious，and the difference was statistically significant(P<0.05).Conclusion:Jiawei Shentong Zhuyu Decoction can improve the biomechanical properties of bone and correct the degenerative changes of bone by reducing the content of BGP and PINP in serum of osteoporosis model rats，so as to achieve the goal of treating osteoporosis.