To investigate the effects of Danhuang Tongmai Recipe on inflammatory response and cerebral blood flow in rats with carotid atherosclerotic stenosis. Methods:A total of 80 SPF and male Sprague-Dawley rats were randomly divided into a normal group (n＝20), a positive control group (n＝20), a model group (n＝20) and an experimental group (n＝20). Rats in the positive control group, the model group and the experimental group were treated with high-fat plus methionine compound feed combined with carotid artery balloon injury to construct a rat model of carotid atherosclerotic stenosis. The normal group was fed with normal feed and no ballooning of the common carotid artery was performed. After successful modeling, rats in the positive control group were given simvastatin 2.5 mg/kg by intragastric administration, and rats in the experimental group were administered with Danhuang Tongmai Recipe 20 g/kg (concentration：10 mL/kg). The normal group and the model group were given the same amount of normal saline twice a day, and each group was continuously administered 8 weeks. After the intervention, the levels of TC, TG, LDL-C and HDL-C in the serum of the rats in each group were detected by automatic biochemical analyzer; The levels of TNF-α, IL-6, CRP and Hcy in the serum of each group were detected by ELISA; HE staining was used to observe the pathological changes of carotid artery in rats; The cerebral blood flow of each group was measured by laser Doppler flowmetry. Results:Compared with the normal group, the levels of TC, TG, LDL-C, TNF-α, IL-6, CRP and Hcy in the model group and experimental group significantly increased, while HDL-C significantly reduced; Compared with the model group, TC, TG, LDL-C levels, inflammatory factors TNF-α, IL-6, CRP and Hcy levels significantly reduced in the positive control group and the experimental group, while HDL-C significantly increased (P<0.05); At the same time, compared with the normal group, the cerebral blood flow significantly reduced in the model group and the experimental group; Compared with the model group, the cerebral blood flow of the positive control group and the experimental group significantly increased (P<0.05). Conclusion:Danhuang Tongmai Recipe can effectively reduce the blood lipids of rats with carotid atherosclerotic stenosis, with anti-inflammatory effects, which can reduce the level of inflammatory mediators. At the same time, it can also increase cerebral blood flow, which is worthy of clinical recommendation.