Based on data mining technology，to explore the medication rules of traditional Chinese medicine(TCM)compound treatment of acid reflux，which syndrome is heat stagnation in the liver and stomach.Methods:Taking the Chinese prescription database as the retrieval database，the traditional Chinese medicine(TCM)prescription for treating acid reflux was searched.The prescriptions for the treatment of heat stagnation in the liver and stomach was selected according to the efficacy，and Excel，SPSS 20.0 software was used for frequency analysis and factor analysis.Results:Chinese herbal compound treatment of acid reflux involved 291 prescriptions，which used for heat stagnation in the liver and stomach syndrome were 69，107 kinds of Chinese medicine，25 flavors of high frequency herbs，Pericarpium Citri Reticulatae，Radix Glycyrrhizae，Radix Aucklandiae，Fructus Amomi Villosi，Pericarpium Citri Reticulatae Viride and Cortex Magnoliae Officinalis were commonly used.In the aspect of efficacy，qi regulating herbs，resolving dampness herbs，activating blood and resolving stasis herbs，eliminating food herbs and clearing heat herbs were most commonly used.Herbs with pungent and bitter tastes were commonly used; the meridian of spleen，stomach and liver were most commonly chosen; 7 groups of affecting heat stagnation in the liver and stomach syndrome were extracted; 8 drug groups were obtained by cluster analysis.Conclusion:The results of this study have many similarities with Professor Tian Delu's application of the "clearing and descending" method to treat acid reflux.