To systematically evaluate the efficacy and safety of acupoint application with Chinese herbal medicine in the treatment of migraine.Methods:Randomized controlled trials(RCTs)of acupoint application with Chinese herbal medicine in the treatment of migraine were retrieved from Chinese and foreign databases till November 2018.After screening literature according to inclusion criteria and exclusion criteria，methodological quality of the included trials was evaluated and the curative effect was comprehensively analyzed.Results:A total of 175 cases were included in 2 studies，and the methodological quality of the included RCTs was relatively poor.The studies showed that acupoint application with Chinese herbal medicine may have advantages in relieving migraine，reducing attack frequency and shortening attack time.Conclusion:Acupoint application with Chinese herbal medicine may have advantages in the prevention and treatment of migraine，but there is no relevant high-quality research at present.