To observe the clinical efficacy of Huangkui Capsules in treating primary nephrotic syndrome and its effects on the microinflammatory state and the expression of angiopoietin like protein 3.Methods:A total of 120 cases of primary nephrotic syndrome in Chongqing Seventh People's Hospital from March 2016 to March 2018 were selected and randomly divided into an observation group and a control group according to random number table，with 60 cases in each group.The control group was given low salt low fat and low protein diet，and also given anticoagulant，anti PLT aggregation，lipid lowering，diuresis，and hormones treatment.On the basis of the control group，the observation group was given Huangkui Capsules，5 capsules per time，each in the morning，noon，and evening.Both groups were treated for 2 months as one treatment course.The levels of 24 hours urine protein，serum albumin(Alb)and serum creatinine(Scr)were detected for comprehensive biochemical indicators of primary nephrotic syndrome.The level of IL-6，IL-8 and TNF-α in the serum of patients was detected for the microinflammatory condition.For angiopoietin like protein 3(ANGPTL3)，routine renal biopsy was performed in the 2 groups of patients before and after treatment.Routine paraffin embedded fixation was carried out in the renal tissue.The routine section and immunohistochemical staining of ANGPTL3 were carried out by the special subjects of the pathology department.The average value of immunohistochemical index was obtained from 10 views，and then the data were analyzed statistically.Results:1)The total effective rate of the observation group was 83.33%，while the total effective rate of the control group was 65.00%.After the chi square test analysis，the total effective rate of the 2 groups had statistical analysis difference(P<0.05)，and Huangkui Capsule had certain clinical effects on primary nephrotic syndrome.2)Among the 3 indexes of the 2 groups after treatment，24 h urine protein and Scr decreased significantly(P<0.05)，while Alb significantly increased(P<0.05).The decrease degree of 24 h urine protein and Scr and the improvement of Alb in the observation group were better than those of the control group(P<0.05).3)After treatment，IL-6，IL-8 and TNF-alpha of the 2 groups were all significantly down-regulated(P<0.05).The down-regulation of Huangkui capsule to IL-6，IL-8 and TNF-alpha in the observation group was better than that of the control group(P<0.05).4)After treatment，the immunization index of ANGPTL3 in the 2 groups decreased significantly(P<0.05).The decrease degree of the ANGPTL3 immunization index in the observation group was better than that of the control group(P<0.05)，and there was a positive correlation between the ANGPTL3 and IL-6，IL-8 and TNF-α.Conclusion:Huangkui Capsules has a better clinical effect in treating patients with primary nephrotic syndrome，suppressing microinflammatory state and decreasing angiopoietin like protein 3.