To observe the effects of Xuanfu Lixue Decoction on senile depression patients with type 2 diabetes of spleen deficiency and qi stagnation. Methods:A total of 80 elderly patients with type 2 diabetes with spleen deficiency and qi stagnation were randomly divided from Oct 2016 to Oct 2018 into control group (40 cases) was treated with basic diabetes treatment combined with imipramine for 4 weeks，and the observation group (40 cases) was treated with basic diabetes treatment combined with Xuanfu Lixue Decoction for 4 weeks.The therapeutic effects of the 2 groups were compared. The efficacy, SDS score, TCM syndrome score, blood glucose index, quality of life and adverse reactions were compared between the 2 groups. Results:The effective rate of treatment in the observation group was higher than that in the control group (P<0.05). After treatment, SDS score, TCM syndrome score, HbA1c level, total score of DSQL and incidence of adverse reactions in the observation group were lower than those in the control group (P<0.05), but fasting plasma glucose (FPG) and 2-h postprandial plasma glucose (2 hPG) were not significantly different from the control group (P>0.05). Conclusion:Xuanfu Lixue Decoction can significantly improve the depression and clinical symptoms of senile depression patients with type 2 diabetes of spleen deficiency and qi stagnation, and help to stabilize blood sugar and improve the quality of life.