To analyze the clinical effect of Daqinglong Decoction on infantile asthma with syndrome of external cold and internal heat.Methods:A total of 118 children with asthma of external cold and internal heat syndrome admitted to Feicheng Mining Central Hospital from January 2017 to December 2017 were selected as the subjects.According to the order number，they were randomly divided into a control group and an observation group，with 59 cases in each group.All the children were given anti-infection，anti-inflammation and symptomatic treatment according to the standard of western medicine treatment for infantile asthma.On the basis of conventional treatment，the observation group was treated with modification based on Daqinglong Decoction according to TCM syndromes in children.Two groups of children were treated for 2 consecutive weeks as a course of treatment，continuous treatment for 2 courses.The severity of TCM clinical symptoms was quantitatively graded by experienced Chinese physicians every 3 days before and after treatment，and the curative effect was judged according to the changes of symptom scores before and after treatment，and the improvement time of clinical symptoms was counted and compared.Serum IgE，IL-4，TNF-a and arterial blood gas indexes(pH value，partial pressure of carbon dioxide，partial pressure of oxygen，oxygen saturation)were measured and compared before and after treatment.After completion of treatment，the clinical efficacy of the 2 groups was evaluated and compared.The adverse drug reactions/side effects of the 2 groups were compared during the treatment period.Results:1)After 4 weeks of treatment，the scores of asthma，cough，chest tightness and shortness of breath of the 2 groups were significantly decreased than before treatment，and the observation group was significantly lower than those in the control group(P<0.05).The improvement time of asthma，cough，chest tightness and shortness of breath in the observation group was significantly shorter than that in the control group(P<0.05).The effective rate of all symptoms were higher than the control group(P<0.05). 2)The serum IgE，IL-4，TNF-α of the 2 groups were decreased than before treatment，and the study group was lower than the control group(P<0.05). 3)After treatment，the arterial blood gas index PO2 in both groups was lower than before treatment，and the study group was lower than that in the control group.PO2 and SatO2 were higher than before treatment，and the study group was higher than the control group(P<0.05). 4)After treatment，the total clinical efficacy rate of the treatment group was significantly higher than that of the control group(P<0.05).5)There were no serious adverse drug/toxic side effects collected in the treatment process of the 2 groups of children，and there was no statistical significance in the adverse drug reaction rate between the 2 groups(P > 0.05).Conclusion:Daqinglong Decoction can reduce inflammation and enhance arterial oxygen exchange ability in children with asthma of external cold and internal heat syndrome，so as to rapidly improve clinical symptoms and enhance clinical efficacy，and it is safe and has high clinical value.