To analyze the effects of Shexiang Baoxin Pills on cardiac function in patients with acute myocardial infarction(AMI).Methods:A total of 118 cases of AMI patients who were treated in Shandong Provincial Third Hospital during September 2014 to February 2018 were chosen as research subjects.Treatment methods were retrospectively analyzed，and all patients were divided into a control group(n＝60)underwent conventional thrombolytic therapy，and a study group(n＝58)underwent Shexiang Baoxin Pills combined with thrombolytic therapy.14 d was used as a course.The changes of left ventricular ejection fraction(LVEF)and stroke volume(SV)were compared before and after treatment between the 2 groups，as well as serum angiogenesis indexes ［vascular endothelial growth factor(VEGF)，basic fibroblast growth factor(bFGF)］ and inflammatory factors ［tumor necrosis factor α(TNF-α)and calcitonin(PCT)，interleukin-1β(IL-1β)，interleukin-6(IL-6)］.Results:Before treatment，there were no significant difference in levels of cardiac function parameters，serum contents of angiogenesis indexes and inflammatory factors between the 2 groups(P>0.05).14 d after treatment，levels of LVEF and SV in the observation group were higher than those in the control group.Serum contents of VEGF and bFGF in the observation group were higher than those in the control group.Contents of TNF-α，PCT，IL-1β and IL-6 in the observation group were lower than those in the control group(P<0.05).Conclusion:Treatment of thrombolytic therapy and Shexiang Baoxin Pills for AMI patients can further optimize the heart function，and the specific mechanism may be related to Shexiang Baoxin Pills for angiogenesis and anti-inflammatory.