To observe clinical efficacy of modified Chaihu Shugan Powder in chronic superficial gastritis(CSG)with liver-stomach disharmony，and to explore therapeutic mechanism and its clinical value in treating CSG.Methods:A total of 112 patients with liver-stomach disharmony type CSG who were treated in Hengshui People's Hospital from March 2017 to February 2018 were selected as subjects and randomly divided into control group and observation group，with 56 cases in each group.The 2 groups of patients were treated according to conventional CSG scheme，then Chaihu Shugan powder was taken as the basic formula in the observation group to perform syndrome differentiation，modification and treatment.Two weeks was 1 course of treatment，and the 2 groups of patients were treated for 2 consecutive courses of treatment.Efficacy in main symptoms，efficacy in gastroscopic gastric mucosal improvement and clearance rate of Helicobacter pylori(HP)were compared between the 2 groups after the treatment.Changes of serum interleukin-2 and interleukin-6(IL-2 and IL-6)，tumor necrosis factor-α(TNF-α)，chemokine-1(MCP-1)，CRP and SF-36 quality of life scores before and after the treatment were compared between the 2 groups.Rates of adverse drug reactions/toxic and side effects during the treatment were compared between the 2 groups.Results:1)After 2 courses of the treatment，the scores of main clinical symptoms such as postprandial distension and discomfort，early satiety，upper abdominal pain or discomfort，and burning sensation in the 2 groups were significantly decreased compared with those before the treatment，and those in the observation group were lower than those in the control group(P<0.05).After the treatment，total effective rates of the above symptoms in the observation group were significantly higher than those in the control group(P<0.05).2)The serum levels of IL-2，IL-6，TNF-α，MCP-1 and CRP in the 2 groups were significantly lower than those in the control group after the treatment，and those in the observation group were lower than those in the control group.3)After the treatment，the HP clearance rate in the observation group was significantly higher than that in the control group(P<0.05).4)After the treatment，the total effective rate of gastroscopic gastric mucosal improvement in the observation group was significantly higher than that in the control group(P<0.05).5)There were no serious adverse reactions/toxic and side effects during the treatment in the 2 groups.There was no significant difference in general adverse reactions/toxic and side effects(P>0.05).Conclusion:Syndrome differentiation，modification and treatment of Chaihu Shugan Powder can effectively improve the clearance rate of HP，decrease the inflammatory state of patients and the levels of immune-related inflammatory factors in CSG with liver-stomach disharmony，so as to improve the clinical symptoms and quality of life for patients with CSG.It is safe and has high clinical value.