To investigate the effects of Zhenggan Huazheng Decoction combined with Aidi injection on the liver function of patients with primary liver cancer.Methods:A total of 66 patients with primary liver cancer from October 2015 to April 2017 were enrolled in Hainan Provincial Hospital of TCM and were randomly divided into a control group and an observation group according to random number table，with 38 cases in each group.The control group was treated with transcatheter arterial chemoembolization(TACE)，and the study group was treated with Addie injection+Zhenggan Huazheng Decoction on the basis of the control group.Both groups were treated for 1 month continuously.The clinical curative effect，immune function indexes(CD3+，CD4+，CD8+，CD4+/CD8+)，liver function indexes ［total bilirubin(TBil)，aspartate aminotransferase(AST)，glutamate aminotransferase(ALT)］，alpha fetoprotein(AFP)，carcinoembryonic antigen(CEA)and quality of life(EORTC QLQ-30)score at the time of admission and after the end of the course of the 2 groups were statistically recorded.Results:The total effective rate of the study group(89.47%)was higher than that of the control group(71.05%)，and the difference was statistically significant(P<0.05).There was no significant difference in serum CD3+，CD4+，CD8+，CD4+/CD8+ levels between the 2 groups before treatment(P>0.05).After treatment，the serum CD3+，CD4+，CD8+，CD4+/CD8+ levels in the study group improved more than the control group，and the CD8+ level was lower than the control group，with significant difference(P<0.05).There was no significant difference in serum TBil，AST and ALT levels between the 2 groups before treatment(P>0.05).After treatment，compared with the control group，the serum levels of TBil，AST，ALT and other liver function indexes in the study group were significantly decreased，and the difference was statistically significant(P<0.05).Compared with the control group，the EORTC QLQ-30 scores in the 2 groups were significantly increased after treatment，and the difference was statistically significant(P<0.05).There was no significant difference in serum AFP and CEA levels between the 2 groups before treatment(P>0.05).After treatment，serum AFP and CEA levels were decreased than before treatment，and the study group was lower than the control group.The difference was statistically significant(P<0.05).Conclusion:On the basis of routine treatment，the combined intervention of Addie injection and Zhenggan Huazheng Decoction on patients with primary liver cancer can effectively improve their liver function，regulate the immune function，reduce serum tumor markers AFP and CEA expression，improve the therapeutic effect and restore the quality of life of patients.