To explore the effects of Yinzhihuang Injection on Hcy and γ-GT in patients with hyperbilirubinemia after liver transplantation.Methods:A total of 80 patients with hyperbilirubinemia after liver transplantation admitted to Shanghai Changzheng Hospital from January 2015 to January 2018 were divided into a control group(n＝40)and an observation group(n＝40)according to random number table method.The control group was treated with Yousifu on the basis of anti-rejection and anti-virus.The observation group was treated with Yinzhihuang Injection on the basis of the control group.Both groups were treated for 4 weeks.The clinical efficacy of the 2 groups was counted，and the differences of liver function indexes(DBIL，ALT，AST)，serum total bilirubin，Hcy and γ-GT between the 2 groups before and after treatment were compared.Results:After treatment，the clinical total effective rates of the observation group and the control group were 95.00% and 75.00%，and the observation group was significantly higher than the control group(P<0.05).Compared with before treatment，the serum total bilirubin values of the observation group were significantly lower than those of the control group(P<0.05)，and the changes of DBIL，ALT and AST in the liver function indexes of the observation group were significantly lower than those of the control group(P<0.05).The indexes of Hcy and γ-GT in the observation group were significantly lower than those in the control group 4 weeks after treatment(P<0.05).Conclusion:Yinzhihuang Injection can effectively alleviate the clinical symptoms of hyperbilirubinemia after liver transplantation.It can significantly improve the indexes of liver function(DBIL，ALT，AST)，serum total bilirubin，Hcy and γ-GT，and has better curative effects than Yousifu therapy.It is worthy of clinical application.