To observe the clinical efficacy and hematologic changes of Yangxinshi Tablets combined with routine western medicine in the treatment of coronary heart disease after PCI.Methods:A total of 84 patients with coronary heart disease after PCI who were treated in the Affiliated Hospital of Qingdao University from April 2017 to December 2018 were selected and randomly divided into an observation group and a control group，with 42 patients in each group.The control group was treated with routine western medicine of coronary heart disease after PCI，while the observation group received Yangxinshi Tablets on the basis of routine treatment with the course of 8 weeks.The changes of angina symptoms，electrocardiogram，endothelial function，inflammatory factors and lipid levels of the 2 groups before and after treatment were recorded and evaluated.Results:The total effective rate of angina in the observation group was 90.48%，which was significantly higher than 61.90% of the control group.The total effective rate of ECG of the observation group was 92.70%，which was significantly higher than 57.14% of the control group.There were significant differences in the endothelial function，inflammatory factors and lipid levels between the observation group and the control group(P<0.05).Conclusion:Yangxinshi Tablets combined with routine western medicine can significantly improve the angina symptoms，ECG abnormity，endothelial function and lipid abnormality of coronary heart disease patients after PCI as well as restrain inflammation.The curative effect of Yangxinshi Tablets is reliable.